Overview
Isotretinoin is a vitamin A derivative approved for severe, scarring acne that has not responded to other treatment.
This listing is Zionova Accutane 20mg (20 mg), photographed as we ship it and priced in Canadian dollars.
How it works
Isotretinoin shrinks oil glands and reduces oil production, inflammation and the bacteria that drive acne.
Clinical reference
Canadian labelling is 0.5 to 1 mg per kilogram of body weight a day, divided into two doses with food, usually for 15 to 20 weeks.
Reference information from product labels and clinical literature only. It is not a recommendation or dosing advice for you; any use should be set and monitored by a doctor.
Measuring calculator
Type the amount from your prescription or clinician; the calculator only converts it. It does not suggest how much to take.
Combinations and interactions
- Do not combine with vitamin A supplements or tetracycline antibiotics (risk of raised brain pressure).
- Avoid alcohol, which adds to liver and lipid effects.
Risks and side effects
- Birth defects. Severe birth defects; pregnancy must be avoided completely.
- Dryness. Dry lips, eyes and skin are almost universal.
- Mood. Depression and mood changes are reported.
- Liver and lipids. Triglycerides and liver enzymes can rise.
Do not use it if you are or could become pregnant, are breastfeeding, have high triglycerides, liver disease or a history of depression.
Bloodwork to discuss with your doctor
- Lipid panel (triglycerides)
- Liver enzymes
- Pregnancy test for anyone who could become pregnant
Peer-reviewed papers behind the facts on this page, each linked to its PubMed record.
Chemistry
Isotretinoin
Research
Storage and handling
Keep the bottle tightly closed at room temperature, away from moisture, heat and children. Do not move tablets into unlabelled containers.
Canadian legal status
This is a prescription medicine in Canada. A doctor should assess whether it suits you, choose the dose and monitor you while you use it.
FAQ
What strength are the tablets?
The Zionova bottle lists 20 mg tablets, 50 per bottle.
Should I take it with food?
Yes, absorption is much better with fatty food.
Can I donate blood while taking it?
No, not during treatment or for a month after.
How fast will it reach me?
Orders leave Vancouver by Canada Post Xpresspost and the tracking number arrives within 72 hours of your e-Transfer. Most provinces receive parcels 1 to 6 business days after that; the territories can take up to 10. Xpresspost is free on orders over $300, and a lost or seized parcel is reshipped at no charge.
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