The Nolvadex family of medicines include anastrozole and clomiphene citrate. The most common adverse reactions associated with the use of these medicines are liver irritation and gastric or duodenal ulcers. These are common to the family and also occur in other medicines. However, some other side effects like skin rash, skin sensitization and hair loss may also occur with some patients.
The Nolvadex drug name was withdrawn from the U.S. by the FDA in 2020. When generic versions of the drug were approved by the FDA there might still be generic alternatives available. However, this is not an exhaustive list of medicines or conditions which can interact with Nolvadex.
This medicine is a rare type of tamoxifen and it works differently than tamoxifen. While the former blocks the production of estrogen and progesterone, the latter prevents the conversion of testosterone to DHT. In a patient taking a combination of these medicines, the hormone replacement therapy can cause severe birth defects. The reason for this is that both the tamoxifen and Nolvadex block the conversion of testosterone to DHT. In a patient who is taking a tamoxifen like medication, the hormone replacement treatment may produce an undesirable increase in the level of DHT in the body.
The side effects of Nolvadex can range from nausea to vomiting and abdominal pain, and in some cases the patient may feel dizzy. Some side effects are temporary and usually go away when the medication is stopped, while other may last longer. Patients taking Nolvadex should avoid aspirin and other medications that contain aspirin like drugs as they can interfere with the effectiveness of the medicine.
The most commonly reported side effect of this medication is that it can increase the level of liver enzymes in the body and hence may result in liver toxicity. Since Nolvadex is used for long periods of time, liver damage may occur. It may also cause a dry mouth and sore throat due to increased uric acid levels in the blood.
Nausea and vomiting are common, as are headaches and stomach aches in patients on Nolvadex. The above mentioned side effect of Nolvadex can also be caused by a number of side effects. For example, the medications can cause increased heart rate and increase blood pressure. The other Nolvadex side effects include nausea, increased appetite, diarrhea and headaches. Also, there is an increase in the risk of having cancer in a patient taking Nolvadex if the patient is taking tamoxifen.
There is no need for a patient to worry if Nolvadex does not cause any side effects in them since many of the medicines that contain tamoxifen like drugs can cause a dangerous increase in the level of liver enzymes. However, if the medicines contain estrogen like ingredients like tamoxifen, estrogen can cause a number of side effects like breast changes, vaginal bleeding, nausea, breast pain, hair loss, hot flashes, mood changes, vaginal itching, changes in vision, and even cancer.
Although Nolvadex has not been proven to cause any serious side effects, it is important to know about the possible side effects and not take this medicine for a prolonged period of time if the doctor advises it because this can lead to severe complications. Nolvadex should be taken under the supervision of a physician as well.
Women who are pregnant or planning to get pregnant should not take Nolvadex as it may cause birth defects. However, some studies have shown that it may not affect the fertility of women.
The FDA has not approved Nolvadex as safe to use during pregnancy. In a study, nine women who were undergoing ovulation monitoring were given Nolvadex to induce ovulation. After ten weeks of continuous use, one woman had a miscarriage.
Nolvadex is a very powerful drug. It can produce some serious side effects, which can be very disturbing if taken for a prolonged time period of time. A patient should only take it when prescribed by a doctor. This is because the longer that the medication is used, the more the chances for having serious complications develop.